CpG-ODN免疫佐劑
CPG ODN(CpG oligonucleotide, CpG寡脫氧核苷酸)是人工合成的含有非甲基化的胞嘧啶鳥嘌呤二核苷酸(CpG)的寡脫氧核苷酸(ODN),可模擬細(xì)菌DNA刺激多種哺乳動(dòng)物包括人的免疫細(xì)胞。不同類型的CpG ODN的結(jié)構(gòu)特征與免疫效應(yīng)各有不同,一般分為A、B、C三類,泓迅生物能夠提供多種屬的三種類型的CpG ODN。
● A類CpG ODN以含有CpG二核苷酸的回文序列為核心,兩端為poly G尾,磷酸二酯鍵骨架為部分硫代修飾,通過回文序列和poly G形成高級(jí)結(jié)構(gòu),能夠活化漿細(xì)胞樣樹突狀細(xì)胞誘生大量I型干擾素,對(duì)B細(xì)胞活性弱。
● B類CpG ODN是一種全硫代修飾的線性CpG ODN,對(duì)B細(xì)胞有很強(qiáng)的免疫刺激活性,但不能活化漿細(xì)胞樣樹突狀細(xì)胞。
● C類CpG-ODN是一類全硫代修飾的CpG ODN,能通過回文序列形成二聚體,兼具A型和B型CpG-ODN的活性,既能活化漿細(xì)胞樣樹突狀細(xì)胞,又能活化B細(xì)胞。
產(chǎn)品優(yōu)勢
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- 純度>95%
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- 內(nèi)毒素水平<5EU/mg
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- 穩(wěn)定性極佳
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- 批次一致性
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產(chǎn)品列表
Name
|
Cat(#)
|
Species
|
Size/Tube
|
CpG ODN 1585
|
SOC-A1585
|
Mouse
|
1mg
|
CpG ODN 2216
|
SOC-A2216
|
Human Preferred
|
1mg
|
CpG ODN 2336
|
SOC-A2336
|
Human Preferred
|
1mg
|
CpG ODN 1668
|
SOC-B1668
|
Mouse
|
1mg
|
CpG ODN 1826
|
SOC-B1826
|
Mouse
|
1mg
|
CpG ODN 2006/7909
|
SOC-B2006
|
Human Preferred
|
1mg
|
CpG ODN 2007
|
SOC-B2007
|
Bovine/Porcine
|
1mg
|
CpG ODN BW006/684
|
SOC-BW006
|
Human&Mouse
|
1mg
|
CpG ODN D-SL01
|
SOC-BDSL01
|
Multispecies
|
1mg
|
CpG ODN 2395
|
SOC-C2395
|
Human/Mouse
|
1mg
|
CpG ODN M362
|
SOC-CM362
|
Human/Mouse
|
1mg
|
CpG ODN D-SL03
|
SOC-CDSL03
|
Multispecies
|
1mg
|
CpG ODN 10101
|
SOC-10101
|
Human&Mouse
|
1mg
|
CpG ODN IMT504
|
SOC-IMT504
|
Human&Mouse
|
1mg
|
CpG ODN 1982
|
SOC-1982
|
Human&Mouse
|
1mg
|
CpG ODN 2088
|
SOC-2088
|
Human&Mouse
|
1mg
|
CpG ODN 21158
|
SOC-21158
|
Human&Mouse
|
1mg
|
CpG ODN 4084-F
|
SOC-4084-F
|
Human&Mouse
|
1mg
|
CpG ODN 5328
|
SOC-5328
|
Human&Mouse
|
1mg
|
CpG ODN BW001
|
SOC-BW001
|
Human&Mouse
|
1mg
|
CpG ODN INH-1
|
SOC-INH-1
|
Human&Mouse
|
1mg
|
CpG ODN M326
|
SOC-M326
|
Human&Mouse
|
1mg
|
CpG ODN TTAGGG
|
SOC-TTAGGG
|
Human&Mouse
|
1mg
|
常見問題
發(fā)貨形式默認(rèn)1 mg/管發(fā)貨,不分裝??蛻羰盏胶罂梢匀芙夥盅b冷凍,一次取用一管。
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